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How to disable usb in windows

Disable USB Drives and Mass Storage Devices using Registry

If the administrator is smart then he would definitely do this to ensure a tight blockade. He would alter the settings through regeditcommand on run console. Now how do you unlock it ? You have to go right into where the administrator has been. Here is how.
  1. Go to Start > Run , type “regedit” and press enter to open the registry editor
  2. Navigate to the following key

In the right pane, select Start and the default value is 3 u can change the value to 4. (The value 4 will disable USB Storage). Click OK. This will re-enable USB Ports and allow you to use USB or Pen drives.